Manchester City were held 1-1 at Stoke on Saturday evening, and Roberto Mancini's men are now out to 11/5 with StanJames.com to take the Premier League title.
The firm's spokesman Rory Jiwani says, "City may be top on goal difference, but Manchester United are hot favourites to win at home to Fulham on Monday night and go three points clear which is a crucial advantage at this stage of the season.
"With United appearing to have the slightly easier run-in, we've cut them from 1/2 to 1/3 to retain their title with City 11/5 from 6/4 to seize the crown. City must win the Manchester derby at the Etihad on April 30th but they also face difficult trips to Arsenal and Newcastle and it looks like United's title to lose.
"Arsenal are all but assured of a Champions League spot after beating Aston Villa 3-0 to clinch their seventh straight league win in a row. We make them 1/25 to finish in the top four with Tottenham 3/20 and Chelsea 11/4 after the pair played out a goalless draw at Stamford Bridge.
"At the bottom, Wolves look doomed after going down at Norwich while Wigan boosted their survival hopes with a shock 2-1 win at Liverpool. We make Wolves 1/10 favourites to go down with Wigan and QPR both 3/10 to be relegated to the Championship. Bolton are out to 7/4 after they beat Blackburn with Steve Kean's men now 11/4 for the drop.
Barclays Premier League Outright: 1/3 Manchester United 11/5 Manchester City 150 Arsenal
Barclays Premier League Top 4 Finish: 1/25 Arsenal 3/20 Tottenham 11/4 Chelsea 20 Newcastle 50 Liverpool
Barclays Premier League Relegation: 1/10 Wolves 3/10 Wigan, QPR 7/4 Bolton 11/4 Blackburn 16 Aston Villa 50 Norwich